Should you adjust for baseline characteristics within randomized controlled trials?
Healthcare ECONOMIST
NOVEMBER 19, 2022
At first glance, one may think the answer is no. Randomization should insure that baseline characteristics are balanced across trial arms. In practice, however, sometimes baseline characteristics due differ somewhat by trial arm simply by chance, especially in smaller randomized controlled trials (RCTs). A JAMA Guide to Statistics and Methods by Holmberg et al. 2022 provides justification for why you would want to adjust for baseline characteristics in many cases. …adjusting for baseline c
64 
Let's personalize your content